Peer-reviewed medical journal articles on cluster headache and related conditions.

We have tried to link directly to PDF copies of articles where available for online viewing or download. In some cases, links may be directed to the Abstract only. These articles may require a subscription or one-time purchase in order to access to the journal article. Fees vary. For free or low-cost access to journal articles, please visit patientAccess, PubMed Central, or SpringerLink.

CHSG is not responsible for any fees incurred nor does it receive any payment, royalty, commission, or other compensation as a result of these links.

Article topics

  • Calcitonin gene-related peptide antagonism and cluster headache: an emerging new treatment August 30, 2017
    Calcitonin gene-related peptide (CGRP) is a key signaling molecule involved in migraine pathophysiology. Efficacy of CGRP monoclonal antibodies and antagonists in migraine treatment has fueled an increasing interest in the prospect of treating cluster headache (CH) with CGRP antagonism. The exact role of CGRP and its mechanism of action in CH have not been fully ...
  • Economics of Inhaled Oxygen Use as an Acute Therapy for Cluster Headache in the United States of America August 26, 2017
    The objectives of the study, which covered each of the US states, were to map the current market landscape of medical grade oxygen for use in CH and to develop a cost simulator based on a patient’s needs and geography. Results from our study showed that the current costs for oxygen use as an acute ...
  • Carotid dissection presenting as a prolonged cluster-like headache in a patient with episodic cluster headache August 1, 2017
    We present a patient with known episodic cluster headache, who presented with cluster-like headache in the course of internal carotid artery dissection (ICAD) and discuss possible pathophysiological links between the two diseases. It is well known that cluster-like headache could be the presenting symptom of ICAD. However, ICAD occurring in a patient with a known ...
  • The comorbidity burden of patients with cluster headache: a population-based study July 24, 2017
    Evidence is limited regarding the comorbidity burden of patients with cluster headache (CH). We aimed to characterize comorbid conditions in a cohort of CH patients diagnosed by headache experts, using electronic health record information from the Partners Research Patient Data Registry (RPDR).
  • Cluster and Facial Headache July 8, 2017
    Trigeminal autonomic cephalalgias (TACs) are primary headache disorders characterized by unilateral head pain of varying duration associated with ipsilateral cranial autonomic features.
  • The pathophysiology of episodic cluster headache: Insights from recent neuroimaging research July 5, 2017
    Cluster headache is a disorder characterized by intermittent, severe unilateral head pain accompanied by cranial autonomic symptoms. Most cases of CH are episodic, manifesting as “in-bout” periods of frequent headache separated by month-to-year-long “out-of-bout” periods of remission. Previous imaging studies have implicated the hypothalamus and pain matrix in the pathogenesis of episodic CH. However, the ...
  • Calcitonin Gene-Related Peptide-Targeted Therapies for Migraine and Cluster Headache: A Review July 1, 2017
    Calcitonin gene-related peptide (CGRP) is a signaling neuropeptide released from activated trigeminal sensory afferents in headache and facial pain disorders. There are a handful of CGRP-targeted therapies currently in phase 3 studies for migraine acute treatment or prevention. Currently, 4 monoclonal antibodies targeting either the CGRP ligand or receptor are being studied for migraine prevention: ...
  • Cluster-like Headache Secondary to Focal Cervical Myelitis July 1, 2017
    Cluster headache (CH) is characterized by attacks of severe periorbital pain associated with autonomic symptoms. As with other forms of primary headache, structural lesions should be excluded, particularly if the headache presents with an atypical pattern.
  • The reappearance of hemiplegic cluster headaches: A case report and review of the literature July 1, 2017
    Cluster headache (CH) is a rare and severe syndrome characterized by the recurrence of unilateral pain attacks, of short duration (15–180 min), and associated with ipsilateral cranial autonomic symptoms. Although, not formally included in the International Classification of Headache Disorders, hemiplegic cluster headache (HCH) is an even more rare subtype of CH in which typical attacks ...
  • Allodynia in Cluster Headache June 1, 2017
    Cutaneous allodynia is an established marker for central sensitization in migraine. There is debate whether cutaneous allodynia may also occur in cluster headache, another episodic headache disorder. Here, we examined the presence and severity of allodynia in a large well-defined nationwide population of people with cluster headache.