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In: SPG Nerve Stimulation

Cluster headache is a rare form of primary headache characterised by intense unilateral pain and autonomous nerve symptoms. Pharmacological treatments are sometimes insufficient, which calls for surgical alternatives in treatment refractory cases. Stimulation of the sphenopalatine ganglion (SPG) is a new method shown to be effective for preventing and treating attacks.Read More →

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In: Vagus Nerve Stimulation

In the PREVention and Acute treatment of chronic cluster headache (PREVA) study, attack frequency reductions from baseline were significantly more pronounced with non-invasive vagus nerve stimulation plus standard of care (nVNS + SoC) than with SoC alone. Given the intensely painful and frequent nature of chronic cluster headache attacks, additional patient-centric outcomes, including the time to and level of therapeutic response, were evaluated in a post hoc analysis of the PREVA study.Read More →

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In: Botox, Journal Articles

Condition:   Cluster HeadacheInterventions:   Drug: Botulinum Toxin Type A 25 IU;   Drug: Botulinum Toxin Type A 12.5 IUSponsors:   Norwegian University of Science and Technology;   St. Olavs HospitalRecruiting – verified April 2017 Source: Cluster Headache Clinical TrialsRead More →

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In: Neuromodulation, Pathophysiology

The trigeminal autonomic cephalalgias (TACs) are highly disabling primary headache disorders. There are several issues that remain unresolved in the understanding of the pathophysiology of the TACs, although activation of the trigeminal–autonomic reflex and ipsilateral hypothalamic activation both play a central role. The discovery of the central role of the hypothalamus led to its use as a therapeutic target. After the good results obtained with hypothalamic stimulation, other peripheral neuromodulation targets were tried in the management of refractory cluster headache (CH) and other TACs.Read More →

By:
On:
In: Neuromodulation, Pathophysiology

The trigeminal autonomic cephalalgias (TACs) are highly disabling primary headache disorders. There are several issues that remain unresolved in the understanding of the pathophysiology of the TACs, although activation of the trigeminal–autonomic reflex and ipsilateral hypothalamic activation both play a central role. The discovery of the central role of the hypothalamus led to its use as a therapeutic target. After the good results obtained with hypothalamic stimulation, other peripheral neuromodulation targets were tried in the management of refractory cluster headache (CH) and other TACs.Read More →

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In: SPG Nerve Stimulation

The ATI SPG microstimulator is designed to be fixed on the posterior maxilla, with the integrated lead extending into the pterygopalatine fossa to electrically stimulate the sphenopalatine ganglion (SPG) as a treatment for cluster headache. Preoperative surgical planning to ensure the placement of the microstimulator in close proximity (within 5 mm) to the SPG is critical for treatment efficacy. The aim of this study was to improve the surgical procedure by navigating the initial dissection prior to implantation using a passive optical navigation system and to match the post-operative CBCT images with the preoperative treatment plan to verify the accuracy of the intraoperative placement of the microstimulator.Read More →