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smoking

Effects of grapefruit juice and smoking on verapamil concentrations in steady state

2002-04-01
By: CHSG Admin
On: April 1, 2002
In: Verapamil

Human gut wall cytochrome P450 (CYP)3A4 is inhibited by grapefruit juice (G), whereas smoking increases CYP1A2 activity. Both enzymes contribute to verapamil biotransformation. This study was performed to quantitatively assess the effect of these factors on verapamil pharmacokinetics in steady state. Read More →

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