Peer-reviewed medical journal articles on cluster headache and related conditions.

We have tried to link directly to PDF copies of articles where available for online viewing or download. In some cases, links may be directed to the Abstract only. These articles may require a subscription or one-time purchase in order to access to the journal article. Fees vary. For free or low-cost access to journal articles, please visit patientAccess, PubMed Central, or SpringerLink.

CHSG is not responsible for any fees incurred nor does it receive any payment, royalty, commission, or other compensation as a result of these links.

Article topics

  • TRP Channels as Sensors of Oxygen Availability August 1, 2013
    An ability to adapt to changes in oxygen availability is essential for survival in both prokaryotic and eukaryotic organisms. Recently, cation channels encoded by the transient receptor potential (trp) gene superfamily have been recognized as multimodal sensors of a wide variety of factors inside the cells and in the extracellular environment and also as transducers ...
  • Psychedelics: Considerations Before Use May 23, 2013
    People have been talking about treating cluster headache with psychedelics for years. Here are some things to consider before making the choice.
  • Pathway ch-1 study: sphenopalatine ganglion (spg) stimulation for acute treatment of chronic cluster headache (CCH) February 21, 2013
    The pain and autonomic symptoms of cluster headache result from activation of the trigeminal parasympathetic reflex, mediated through the SPG . We aimed to investigate the safety and efficacy of SPG stimulation for the acute treatment of CCH.
  • Stimulation of the Sphenopalatine Ganglion (SPG) for Cluster Headache Treatment. Pathway CH-1 January 11, 2013
    The pain and autonomic symptoms of cluster headache (CH) result from activation of the trigeminal parasympathetic reflex, mediated through the sphenopalatine ganglion (SPG). We investigated the safety and efficacy of on-demand SPG stimulation for chronic CH (CCH).
  • High-dose intravenous methylprednisolone for the prophylactic treatment of cluster headache December 12, 2012
    Triptans are effective for immediate relief of episodic cluster headache (CH) but do not reduce the frequency of attacks. Intravenous bolus injection of corticosteroids like methylprednisolone (MP) has been reported to decrease the frequency of CH attacks. We validated the prophylactic efficacy of MP pulse therapy by monitoring CH recurrence over several years following treatment ...
  • Emerging Target-Based Paradigms to Prevent and Treat Migraine December 5, 2012
    Migraine is a primary brain disorder resulting from altered modulation of normal sensory stimuli and trigeminal nerve dysfunction. The second edition of the International Classification of Headache Disorders (ICHD-2) defines seven subtypes of migraine. Migraine treatment can be acute or preventive. New targeted therapies include 5-HT1F receptor agonists, calcitonin gene-related peptide (CGRP) antagonists, nitric oxide synthetase ...
  • Use of cannabis among 139 cluster headache sufferers November 29, 2012
    A case report suggested the efficacy of cannabis to treat cluster headache (CH) attacks. Our aims were to study the frequency of cannabis use in CH patients, and the reported effects on attacks. A total of 139 patients with CH attending two French headache centers filled out questionnaires. Cannabis use is very frequent in CH ...
  • Data Collection on the ATI Neurostimulation System: SPG Stimulation for Cluster Headache August 29, 2012
    Condition:   Cluster HeadacheIntervention:   Sponsor:   Autonomic Technologies, Inc.Active, not recruiting – verified May 2017 Source: Cluster Headache Clinical Trials
  • The role of chemosensitive afferent nerves and TRP ion channels in the pathomechanism of headaches August 12, 2012
    The involvement of trigeminovascular afferent nerves in the pathomechanism of primary headaches is well established, but a pivotal role of a particular class of primary sensory neurons has not been advocated. This review focuses on the evidence that supports the critical involvement of transient receptor potential (TRP) channels in the pathophysiology of primary headaches, in ...
  • Cluster headache and neuropsychological functioning June 18, 2012
    Despite significant advances in unravelling the pathophysiology of cluster headache (CH), little is known about neuropsychological functioning. Apart from neuroimaging studies indicating involvement of posterior hypothalamic and other areas frequently involved in nociception, some studies suggest involvement of prefrontal areas. Among others, these mediate executive functioning (EF).