Peer-reviewed medical journal articles on cluster headache and related conditions.

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Article topics

  • Pharmacologic Characterization of AMG 334, a Potent and Selective Human Monoclonal Antibody against the Calcitonin Gene-Related Peptide Receptor January 1, 2016
    Therapeutic agents that block the calcitonin gene–related peptide (CGRP) signaling pathway are a highly anticipated and promising new drug class for migraine therapy, especially after reports that small-molecule CGRP-receptor antagonists are efficacious for both acute migraine treatment and migraine prevention. Using XenoMouse technology, we successfully generated AMG 334, a fully human monoclonal antibody against the ...
  • Safety, tolerability, and efficacy of TEV-48125 for preventive treatment of high-frequency episodic migraine: a multicentre, randomised, double-blind, placebo-controlled, phase 2b study November 1, 2015
    Calcitonin gene-related peptide (CGRP) is a validated target for the treatment of episodic migraine. Here we assess the safety, tolerability, and efficacy of TEV-48125, a monoclonal anti-CGRP antibody, in the preventive treatment of high-frequency episodic migraine.
  • Fluticasone as Treatment for Cluster Headaches October 1, 2015
    Cluster headaches (CHs) are one of the most debilitating of all the identified headache syndromes. Their pathogenesis is poorly understood, which has made their treatment challenging. Various medicines and modalities have been put forth in an effort to minimize the symptoms, but none have proven to be consistently reliable.
  • Demonstration of High Coincidence of Pituitary Adenoma in Patients with Ruptured Rathke’s Cleft Cyst October 1, 2015
    Repeated chronic inflammation, such as under circumstances of ruptured Rathke’s cleft cyst(RCC), is known as the fundamental basis of various pathological changes including neoplastic change,therefore to examine accurate incidence of pituitary adenomas is important for the preventive medicine.
  • Botulinum toxin and the treatment of headache: A clinical review September 10, 2015
    Since its discovery, Onabotulinum toxins have been tried for the treatment of various head, neck and face pain syndromes. The end result of controlled clinical trials was that there was not clear evidence for use in many of the common primary and secondary headaches. In chronic migraine, affecting 1-2% of the population, a fixed site ...
  • High-Dose Verapamil in Episodic and Chronic Cluster Headaches and Cardiac Adverse Events: Is It as Safe as We Think? August 28, 2015
    Cluster headache (CH) is a primary headache disorder with relatively effective treatments. Although few sufficiently controlled trials are available, verapamil is recommended as the first-line prophylactic drug for CH by the French Headache Society (with a low level of evidence, level B) and by the EFNS (European Federation of Neurological Societies, level A). Daily doses ...
  • Neurobiology and sleep disorders in cluster headache August 20, 2015
    Cluster headache is characterized by unilateral attacks of severe pain accompanied by cranial autonomic features. Apart from these there are also sleep-related complaints and strong chronobiological features. The interaction between sleep and headache is complex at any level and evidence suggests that it may be of critical importance in our understanding of primary headache disorders. In cluster headache ...
  • Hallucinogens and related disorders August 12, 2015
    Hallucinogens are as old as civilization. Many cultures recorded eating certain plants specifically to induce visions or alter the perception of reality. Often these hallucinations were part of a religious or prophetic experience. Shamans in Siberia were known to eat the hallucinogenic mushroom Amanita muscaria . The ancient Greeks and the Vikings also used naturally occurring plant hallucinogens. Peyote, ...
  • Trigeminal neuralgia – a coherent cross-specialty management program July 17, 2015
    Optimal management of patients with classical trigeminal neuralgia (TN) requires specific treatment programs and close collaboration between medical, radiological and surgical specialties. Organization of such treatment programs has never been described before. With this paper we aim to describe the implementation and feasibility of an accelerated cross-speciality management program, to describe the collaboration between the ...
  • Targeting CGRP: A New Era for Migraine Treatment June 1, 2015
    Migraine is a highly prevalent headache disease that typically affects patients during their most productive years. Despite significant progress in understanding the underlying pathophysiology of this disorder, its treatment so far continues to depend on drugs that, in their majority, were not specifically designed for this purpose. The neuropeptide calcitonin gene-related peptide (CGRP) has been ...