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Hallucinogens are as old as civilization. Many cultures recorded eating certain plants specifically to induce visions or alter the perception of reality. Often these hallucinations were part of a religious or prophetic experience. Shamans in Siberia were known to eat the hallucinogenic mushroom Amanita muscaria . The ancient Greeks and the Vikings also used naturally occurring plant hallucinogens. Peyote, a spineless cactus native to the southwestern United States and Mexico was used by native peoples, including the Aztecs, to produce visions.Read More →

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The authors interviewed 53 cluster headache patients who had used psilocybin or lysergic acid diethylamide (LSD) to treat their condition. Twenty-two of 26 psilocybin users reported that psilocybin aborted attacks; 25 of 48 psilocybin users and 7 of 8 LSD users reported cluster period termination; 18 of 19 psilocybin users and 4 of 5 LSD users reported remission period extension. Research on the effects of psilocybin and LSD on cluster headche may be warranted.
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