Response of cluster headache to psilocybin and LSD

Authors: R. Andrew Sewell, John H. Halpern and Harrison G. Pope, Jr
Source: Neurology June 27, 2006 vol. 66 no. 12 1920-1922


The authors interviewed 53 cluster headache patients who had used psilocybin or lysergic acid diethylamide (LSD) to treat their condition. Twenty-two of 26 psilocybin users reported that psilocybin aborted attacks; 25 of 48 psilocybin users and 7 of 8 LSD users reported cluster period termination; 18 of 19 psilocybin users and 4 of 5 LSD users reported remission period extension. Research on the effects of psilocybin and LSD on cluster headache may be warranted.
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